It always starts the same way: a sudden temperature drop, a ventilation adjustment made too late, a chilly night in an under-heated brooding house. For a few days the flock looks almost normal — a little sneezing, a few birds with ruffled feathers, feed intake slightly down. Then it moves. Within a week to ten days, poultry respiratory disease has descended from the upper airway into the air sacs, and by the time producers see real mortality, airsacculitis in broilers is already established — with irreversible damage, condemned carcasses, and losses that no treatment can recover. The critical insight for every poultry producer is this: the chain from cold stress to air sac disease is predictable, and every link can be interrupted, but only if action happens early.